The Basilica of St. Clare is an outstanding example of Gothic-Italian architecture, built in the second half of the 13th century and perhaps designed by Filippo da Campello.

The Basilica is attached to the Church of St. George, in which the body of San Francesco was buried before being transferred to its present location. The construction of Basilica is characterized by three large flying buttresses, which are attached to the left side of the building, while a slender bell-tower with a spire rises up from the apse.

The beautiful facade in three orders, decorated by two coloured horizontal bands of stonework, has a beautiful rose window and a portal. The interior, in the form of a Latin cross with a single nave, is simple and bare.

A flight of steps leads down to the Crypt where the mortal remains of St. Clare are contained in a glass coffin. In the right transept is a painting depicting St Clare and "Scenes from the Life of St Clare", believed to be by Cimabue. At the side of the Basilica stands the imposing Monastery of the Poor Clares.