The construction works of the church began in 1619, by the will of Carlo Emanuele I of Savoy and it was dedicated to San Carlo Borromeo, who, after a pilgrimage on foot from London, came to pray before the Holy Sindone.

The current facade, however, is more recent, dating back to 1834, and it is the work of Ferdinando Caronesi.

The gable is decorated with a marble bas-relief depicting Emanuele Filiberto. The squared bell tower and the octagonal cupola were built in 1779. The church is a longitudinal plan of a nave with two chapels on each side. The first chapel on the right and left of the Addolorata and St. Joseph, are the work of Tommaso Carlone and were finished around 1656. The altar is the work of Bernardino Quadri.

The altarpiece depicts San Carlo Borromeo, while in 1578, he went to Turin to see the Shroud of Christ. In addition, between these, there are several paintings of the Caravaggio school.

In the '60s, the night lighting of the church has been designed by Guido Chiarelli.